1.職稱：研究員、優秀青年 3. ? ? ?研究方向：運用生物信息學的方法結合分子生物學技術研究疾病的發生機制；致力于研究可變剪接在干細胞分化、癌癥等疾病發生等方面的作用機理。 4. ? ? ?郵件：luchen@scu.edu.cn 5. ? ? ?個人經歷： 2011年6月－ 2016年8月博士后經歷 (劍橋大學，桑格研究所，英國) ? ? 2008年10月－ 2011年6月博士學位 (巴斯大學, ?英國) ? ? ? 6. ? ? ?代表性論文： （1）Chen L, Bing G, Casale F P et al. 2016. Genetic driversof epigenetic and transcriptional variation in human immune cells. Cell (inpress) （2）Astle WJ, Elding H, Jiang T et al. (including Chen L). 2016. Thousands ofgenetic variants modulate blood cell variation and function in humans. Cell (inpress) （3）Iotchkova V, Huang J, Morris JA et al. (includingChen L).2016.Discovery andrefinement of genetic loci associated with cardiome-x-tabolic risk using denseimputation maps. Nature genetics doi:10.1038/ng.3668. （4）Polfus L M, Khajuria R K, Schick U M et al.(including Chen L). Whole-Exome Sequencing Identifies Loci Associated withBlood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants inHuman Hematopoiesis. The American Journal of Human Genetics.99(2), 481-488 （5）The UK10K Consortium (including Chen L). 2015.The UK10K project: rare variants in health and disease. Nature 526 (7571): 82-90 （6）Vasquez L, Mann L A, Chen L, Soranzo N. 2015. From GWAS to function: lessons fromblood cells. ISBT Science Series (0), 1–9 （7）Tovar-Corona JM, Castillo-Morales A, Chen L et al. 2015. Alternativesplice in alternative lice. Molecular biology and evolution, 32(10), 2749-2759 （8）ChenL,Kostadima M, Martens JH et al. 2014. Transcriptional diversity during lineagecommitment of human blood progenitors. Science345(6204): 1251033.(Highlightedin NatureReviews Genetics). （9）ChenL, Bush SJ, Tovar-Corona JMet al. 2014. Correcting forDifferential Transcript Coverage Reveals a Strong Relationship betweenAlternative Splicing and Organism Complexity. Molecular biology and evolution31(6): 1402-1413. （10）Shin SY, Fauman EB, Petersen AK (including Chen L) et al. 2014. An atlas ofgenetic influences on human blood me-x-tabolites. Nature genetics 46(

運用生物信息學的方法結合分子生物學技術研究疾病的發生機制；致力于研究可變剪接在干細胞分化、癌癥等疾病發生等方面的作用機理。